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Showing posts with the label sorbent monitoring

Monitoring a single C18 particle by confocal Raman microscopy

Solid phase extraction (SPE) is a consolidated sample treatment technique based on the retention of the target analytes in an appropriate sorbent thanks to different chemical interactions. SPE allows the enhancement of the selectivity and sensitivity of an analytical methodology through removing potential interferences and increasing the concentration of the target compounds. The latter depends directly on the extraction efficiency (defined as the absolute extraction recovery), as well as the volumes of the sample processed and the final eluent. Objectively seen, the final elution produces a dilution of the analyte which is previously confined in a lower amount/volume of the sorptive phase, thus reducing the potential enrichment factors of the technique. Solid phase microextraction (SPME) faces up the "elution problem" with a clever strategy that consists on the elution of the analytes inside of the instrument. In this sense, the fiber with the extracted analytes is intr...